Abstract. Long COVID presents ongoing challenges for those experiencing persistent symptoms even
after the acute phase of the illness. Symptoms like shortness of breath, neuropathy, low energy levels,
and vascular complications significantly impact quality of life.
Dysautonomia, another common issue in Long COVID, disrupts the autonomic nervous system, leading
to symptoms like fluctuating heart rate and difficulty regulating body temperature.
Regenesis offers several therapies to address these symptoms:
Hyperbaric Oxygen Therapy (HBOT). HBOT is used for various Long COVID symptoms:
Ozone Therapy. This therapy reduces oxidative stress, boosts immune function, and fights inflammation,
providing relief from Long COVID symptoms.
Stellate Ganglion Block (SGB). SGB resets the autonomic nervous system, offering relief from
dysautonomia symptoms like irregular heart rate and temperature regulation difficulties.
General Vascular Therapy (GVT). GVT targets systemic damage with infused or nebulized therapy,
aiming to alleviate symptoms and promote tissue repair.
Nattokinase. This natural enzyme combats vascular complications and inflammation associated with
Long COVID, promoting blood flow and reducing clotting risk.
Nitric Oxide (NO) Supplementation. NO supplementation improves oxygen delivery and addresses
various Long COVID symptoms, including inflammation, respiratory issues, and neurological symptoms.
The emergence of Long COVID, characterized by persistent symptoms long after the acute phase of the illness, has presents a significant challenge for sufferers. Among its debilitating manifestations are shortness of breath, neuropathy, low energy levels, vascular complications, inflammation, and coagulopathy, which contribute to morbidity and impaired quality of life.
Those suffering from Long COVID may also exhibit dysautonomia in which there is dysfunction or dysregulation of the autonomic nervous system leading to a wide range of symptoms such as fluctuations in heart rate, palpitations, intolerance to heat or cold, difficulties in regulating body temperature, difficulty in maintaining blood pressure and heart rate.
To address these symptoms of Long COVID, Regenesis offers a variety of therapies. These include hyperbaric oxygen therapy, ozone infusions, stellate ganglion block, general vascular bone marrow stemcell (BMSC) infusions with nebulized BMSC, and supplements such as Nattokinase and nitric oxide.
Hyperbaric Oxygen Therapy (HBOT) for Shortness of Breath. Shortness of breath, a hallmark symptom of Long COVID, significantly impairs pulmonary function and diminishes patients' functional capacity. HBOT involves breathing 95% oxygen in a pressurized chamber, thereby increasing oxygen delivery to tissues. HBOT enhances oxygenation, reduces inflammation, and promotes tissue repair, all of which are pivotal in alleviating respiratory distress. By augmenting oxygen availability, HBOT aids in restoring lung function, relieving dyspnea, and improving exercise tolerance in Long COVID patients.
Hyperbaric Oxygen Therapy (HBOT) for Neuropathy. Neuropathy, characterized by nerve damage and dysfunction, is an aftereffect of COVD and one of many symptoms of Long COVID. Peripheral neuropathy manifests as pain, tingling, and numbness in the extremities. It can be progressive, it can profoundly impact mobility and quality of life. HBOT exerts neuroprotective effects by enhancing oxygen delivery to nerve tissues, stimulating angiogenesis (the process through which new blood vessels are formed from pre-existing blood vessels), and modulating inflammatory responses. Clinical evidence suggests that HBOT mitigates neuropathic pain, improves nerve function, and may accelerate nerve regeneration. Thus, HBOT can be valuable as a therapeutic intervention for lessening neuropathic symptoms in Long COVID patients.
Hyperbaric Oxygen Therapy (HBOT) for Low Energy Levels. Fatigue and low energy levels are pervasive complaints among individuals grappling with Long COVID. These symptoms not only impair physical function but also impede cognitive performance and emotional well-being. HBOT combats fatigue by optimizing cellular metabolism, enhancing mitochondrial function, and reducing oxidative stress. By augmenting energy production at the cellular level, HBOT restores vitality, improves cognitive clarity, and enhances overall functional capacity. Long COVID patients undergoing HBOT often report a notable improvement in energy levels, enabling them to reclaim active and fulfilling lives.
The multifaceted benefits of Hyperbaric Oxygen Therapy make it a compelling therapeutic modality for addressing the diverse symptoms of Long COVID. By enhancing oxygen delivery, reducing inflammation, and promoting tissue repair, HBOT offers a holistic approach to symptom management. Particularly in mitigating shortness of breath, neuropathy, and low energy levels, Regenesis offers HBOT in which client breath 95% oxygen within a chamber operating at pressures of 1.3, 1.5, 1.6, 1.8 and 2.0 atmospheres (ATA). Typically, clients require a series of HBOT sessions twice per day and 30 to 60 minutes in duration.
Ozone Therapy. Inflammation, oxidative stress, and immune dysregulation found with Long COVID necessitate novel therapies. To address these symptoms, Regenesis offers ozone therapy to modulate oxidative stress, immune function, and antimicrobial activity.
Ozone enhances oxygen metabolism, stimulates antioxidant enzymes, and attenuates oxidative damage, thereby restoring redox balance. Redox balance, short for reduction-oxidation balance, refers to the equilibrium between oxidants (molecules that accept electrons) and antioxidants (molecules that donate electrons) in biological systems. It is a crucial aspect of cellular function and overall health, as it influences numerous physiological processes, including metabolism, signaling pathways, and immune responses.
Ozone also modulates immune responses, promoting anti-inflammatory pathways and regulating cytokine production. Cytokines are signaling molecules produced by immune cells that regulate inflammation, immune responses, and communication between cells in the body. During the acute phase of COVID-19, dysregulated cytokine production, often termed as a cytokine storm can occur in severe cases, contributing to tissue damage and systemic inflammation. Similarly, in Long COVID, alterations in cytokine profiles may persist and contribute to the ongoing symptoms experienced by patients Finally, ozone's antimicrobial properties combat secondary infections, augmenting the body's defense against opportunistic pathogens.
Benefits of Ozone Therapy in Long COVID. Long COVID is characterized by immune dysregulation, marked by persistent inflammation and impaired immune responses. Ozone therapy modulates immune function by regulating cytokine profiles, enhancing immune surveillance, and promoting regulatory T cell activity, thereby restoring immune homeostasis and attenuating inflammation.
Regenesis offers ozone therapy for ameliorating the diverse manifestations of Long COVID. Its immunomodulatory, antioxidant, and respiratory-supportive properties make it a valuable adjunctive therapy in the management of Long COVID symptoms.
Autohemotherapy with Ozone. Autohemotherapy involves withdrawing a small amount of the patient's blood, mixing it with ozone, and then reintroducing it back into the bloodstream to enhance the body's oxygen utilization and immune response. We perform autohemotherapy in three steps:
The benefits of autohemotherapy with ozone for long COVID include:
Stellate Ganglion Block. To address dysautonomia which can also be an aftereffect of Long COVID, Regenesis offers Stellate Ganglion Blocks (SGB) to reset the autonomic nervous systems. Stellate ganglion blocks (SGBs) are minimally invasive procedures that involve the injection of local anesthetic into the stellate ganglion, a cluster of nerves located in the neck. These blocks can provide therapeutic benefits for patients with dysautonomia, a disorder of the autonomic nervous system, by modulating sympathetic nervous system activity and alleviating symptoms associated with autonomic dysfunction. At Regenesis, our objectives in offering SGB are:
General Vascular Therapy (GVT). When systemic damage to the pulmonary, nervous, or circulatory system is a concern, we offer our patients infused or nebulized therapy in which we provide a patient s bone marrow stem cells back to them with the goals of:
Nattokinase to Counter Spike Damage and Clotting. Among the diverse manifestations of Long COVID are vascular complications, inflammation, and coagulopathy, which contribute to morbidity and impaired quality of life. In this context, Regenesis offers patients Nattokinase, a natural fibrinolytic enzyme dietary supplement derived from fermented soybeans.
Nattokinase exerts its therapeutic effects through the breakdown of fibrin, a key component of blood clots. By enhancing fibrinolysis, Nattokinase promotes blood flow, reduces platelet aggregation, and mitigates thrombotic events. Moreover, Nattokinase exhibits anti-inflammatory properties by modulating cytokine levels and attenuating oxidative stress, thereby addressing the inflammatory cascade characteristic of Long COVID.
Nattokinase in Long COVID presents the following benefits:
Nitric oxide (NO) for Improved Oxygen Profusion. NO is a key signaling molecule involved in various physiological processes, including vasodilation (widening of blood vessels), neurotransmission, immune response, and regulation of inflammation and blood pressure. Changes in NO production can impact cardiovascular health, cognitive function, and overall well-being. NO is naturally produced in the body. Unfortunately, NO production decreases by about 85% between age 25 and age 60. NO is mainly produced by endothelial cells lining blood vessels. Endothelial function decreases with age contributing to a decrease in NO. To offset the effects of aging, Regenesis offers its patients Nitric Oxide Support to supplement natural NO production in the body. While COVID-19 and its associated Spike protein have been implicated in endothelial dysfunction, research on the action of Spike on NO production is ongoing. None the less, due to its manifold benefits, NO supplementation can potentially benefit most patients including those suffering from long COVID. Here's how NO may be beneficial:
As with Nattokinase, nitric oxide is taken daily, typically two capsules in the morning.
At Regenesis our focus is upon harnessing your body’s natural healing processes. As a response to Long- COVID we offer a range of supplements, oxygen therapies, therapies to regain normal function of the autonomic nervous system, and to foster repair of damaged tissues. To learn more, schedule a consult with Dr. Charles Lee.
